Patientcentered outcomes research johns hopkins arthritis. Potential outcomes that can develop in the course of rheumatoid arthritis include frequent flareups, decreased life expectancy, and numerous prognostic possibilities. Patient reported outcomes pros aid in rheumatoid arthritis ra management, but it is not well understood which measures would be most relevant to the rheumatologists for making treatment decisions. Longterm radiographic and patientreported outcomes in patients with rheumatoid arthritis treated with tofacitinib. Review patientreported outcomes as end points in clinical trials in rheumatoid arthritis laure gossec,1,2 maxime dougados,3,4 william dixon5 to cite. Use of patient reported outcomes pros in the routine care of rheumatoid arthritis ra has been shown to improve health outcomes, however, integration of pros into the clinical visit is.
Rheumatoid arthritis, shared decision, physician perspective, patient reported outcomes background determining the best therapeutic approach for patients. Pdf patient reported outcomes in rheumatoid arthritis. Purpose we assessed whether mri measures of synovitis, osteitis and bone erosion were associated with patientreported outcomes pros in a longitudinal clinical trial. Besides physicianassessed disease activity indices, patient. Methods this longitudinal cohort of 291 patients with ra was derived from the mri substudy of the gobefore randomised controlled trial of golimumab among methotrexate. Mallinckrodt announces new clinical data evaluating acthar. Rheumatoid arthritis ra is an autoimmune disease with a prevalence of approximately 0. Jan 20, 2015 rheumatoid arthritis ra is a common chronic inflammatory autoimmune disease characterised by an inflammation of the synovial joints leading to joint and periarticular tissue destruction, as well as a wide variety of extraarticular features see also the separate rheumatoid arthritis and the lung article. The questionnaires used in clinical research have often been developed and validated using paper, and in such cases it is necessary to show that the. In 356 consecutive ra patients, we obtained data on physical function health assessment questionnaire haq, healthrelated quality of life. Patientreported outcomes as end points in clinical trials in. Mnk, a global biopharmaceutical company, today announced data on patientreported outcomes pros showing acthar gel repository corticotropin injection improved disease measures that impact rheumatoid arthritis ra patients with persistently active disease, as well as new data from. Introductionthe place of patient reported outcomes among outcome measures rheumatoid arthritis ra is a systemic, in. Methods this observational study included participants of the care in early ra trial with a rapid and sustained response das28crp patient reported outcomes pros.
It sought to find the most frequently reported outcomes in ra of foot and ankle patients. Electronic tools that include instruments that physicians value to inform their treatment recommendations are limited since collection of this type of data. Potential outcomes for rheumatoid arthritis patients. Introductionthe place of patient reported outcomes among outcome measures. The goal of the treattotarget approach used in rheumatoid arthritis ra is to help patients achieve remission or a state of lowdisease activity lda. Dec 15, 2017 it sought to find the most frequently reported outcomes in ra of foot and ankle patients. Identifying the primary outcome for a randomised controlled. Introduction there is a worldwide interest about the evaluation of rheumatoid arthritis ra from the perspective of the patient, using patientreported outcomes pros, in order to assess. University of pennsylvania, school of medicine, philadelphia, pa, usa 3. To identify the perspectives of patients with rheumatoid arthritis ra on electronic recording of betweenvisit disease activity and other patient reported outcomes pros and on sharing this information with health care providers or peers. Patient versus physicianreported outcomes in rheumatoid. Both objective and patient reported measures are included. Patientreported outcomes as end points in clinical trials. Patient reported outcomes in a trial of combination.
Evidencebased guidelines recommend that patients with rheumatoid arthritis ra be treated with the goal of attaining clinical remission or low disease activity as measured by validated patient andor rheumatologistassessed disease activity measures. Our research is based on understanding patient preferences and focuses on symptoms and patient reported outcomes pro that matter most to people who live with rheumatic diseases. Patientreported outcomes refers to information that comes directly from the patient. Quantifiable measures of patients symptoms such as patient reported outcomes pros provides the physician with quantifiable information of subjective symptoms experienced by patients with rheumatoid arthritis ra. Some pros have been included as part of rheumatoid. Meanwhile, patientreported outcomes have been established in rheumatic diseases, complementary to laboratory measures disease markers, images and examination. The questionnaires used in clinical research have often been developed and validated using paper, and in such cases it is necessary to show that the electronic versions are equivalent to the originals. Patient reported outcomes johns hopkins arthritis center. Objective to assess the clinical evidence for bee venom acupuncture bva for rheumatoid arthritis ra. Longterm course and outcome of functional capacity in rheumatoid arthritis. Reported outcomes measurement information system promis is becoming more widely adopted for research and routine care, and some promis instruments might be substituted for lengthier, legacy pro instruments.
Patientcentered outcomes research pcor combines stateoftheart medical care with a patientcentered approach. Relationship of patientreported outcomes with magnetic resonance imaging measures in rheumatoid arthritis joshua f. Our research is based on understanding patient preferences and. Patient reported outcomes in rheumatoid arthritis clinical. A metaanalysis was conducted using data obtained from three separate randomized controlled clinical trials rcts n 1007. Patient reported outcome measure archives rheumatoid.
Rheumatoid arthritis ra is a chronic inflammatory disease that causes a considerable burden for the patient and society. Patient reported outcomes pros have become an essential part of the assessment of patients with rheumatoid arthritis ra. Relationship of patient reported outcomes with mri measures in rheumatoid arthritis joshua f baker,1,2,3 philip g conaghan,4 paul emery,4 daniel g baker,5 mikkel ostergaard6,7 abstract purpose we assessed whether mri measures of synovitis, osteitis and bone erosion were associated with patient reported outcomes pros in a longitudinal clinical. November 28, 2011 may 15, 2018 kelly oneill young 43 comments measuring rheumatoid disease activity, patient reported outcome measure, research on rheumatoid arthritis so often. Changes in the clinical presentation of patients with rheumatoid arthritis from the early 1990s to the years 2010. Use of patient reported outcomes pros in the routine care of rheumatoid arthritis ra has been shown to improve health outcomes, however, integration of pros into the clinical visit is inconsistent. Patientreported outcomes in rheumatoid arthritis springerlink. To identify the perspectives of patients with rheumatoid arthritis ra on electronic recording of betweenvisit disease activity and other patient reported outcomes pros and on sharing this. The relationship between pain and patient demographics.
Which patient reported outcome domains are important to. Patientreported outcomes pros have become an essential part of the assessment of patients with rheumatoid arthritis ra. The development and application of standardised sets of outcomes to be measured and reported in clinical trials have the potential to increase the efficiency and value. Groundbreaking health system specialty pharmacy quality. In the past, most of the main information used when diagnosing and monitoring patients and assessing. Strong evidence has shown that many patient reported outcomes pros, including healthrelated quality of life, pain, physical.
About the rheumatoid patient foundation rheumatoid patient foundation rpf is a 501c3 nonprofit organization dedicated to improving the lives of people with rheumatoid. Usefulness of patientsreported outcomes in rheumatoid. We recruited rheumatologists nationally to participate in moderated structured group teleconference discussions using the nominal group technique. Outcome measures for use with patients with rheumatoid. Some pros have been included as part of rheumatoid arthritis ra composite outcome measures used in clinical trials cts and clinical assessment for many years.
We aimed to develop a dashboard for ra patients to display relevant pro measures for discussion during a routine ra clinical visit. Recent developments in outcome measures in the rheumatic diseases have been promoted by the development of successful treatments in the past decade. Perspectives of rheumatoid arthritis patients on electronic. We aimed to evaluate the agreement and correlation. Patient centered outcomes research pcor combines stateoftheart medical care with a patient centered approach. Outcome measures in rheumatoid arthritis randomised trials. Patient reported outcomes in rheumatoid arthritis clinical trials article pdf available in current rheumatology reports 174. Comparative efficacy of biologics as monotherapy and in. The identified outcomes were used to populate the list of attributes to be included in the dce. Rheumatoid arthritis ra is a systemic, inflammatory condition with shortterm and with long. Oral start and oral scan posthoc analyses vibeke strand. Longterm radiographic and patientreported outcomes in. Nursing sensitive outcomes in patients with rheumatoid.
Rheumatoid arthritis, shared decision, physician perspective, patient reported outcomes background determining the best therapeutic approach for patients with rheumatoid arthritis ra requires disease activity monitoring at each patient visit 1. Outcome measures in inflammatory rheumatic diseases. To determine whether patient reported outcomes may differentiate treatment response better than physician reported outcomes for rheumatoid arthritis ra patients being treated with anakinra. We will develop a national, highlygeneralizable software platform to electronically capture patient reported outcome pro data for ra patients. Rheumatoid arthritis ra is a chronic inflammatory joint disorder characterised by joint stiffness, swelling, and pain, and can have a profound impact on a patients health related. It is not clear yet whether aiming for remission rem is worthwhile, especially when compared with low disease activity lda. Potential outcomes that can develop in the course of rheumatoid arthritis include frequent flareups, decreased life expectancy, and. For the first time, multiple health system specialty pharmacies, executing the same protocol via enabling software, have demonstrated the capacity to affect patient engagement, collect. The measures have been successfully used in clinical practice, audit and research in the area of rheumatology and with other chronic diseases. One in five patients with rapidly and persistently. Oct 14, 2009 meanwhile, patient reported outcomes have been established in rheumatic diseases, complementary to laboratory measures disease markers, images and examination findings. Review patientreported outcomes as end points in clinical. Which patient reported outcome domains are important to the.
November 28, 2011 may 15, 2018 kelly oneill young 43 comments measuring rheumatoid disease activity, patient reported outcome measure, research on rheumatoid arthritis so often when im listening to a scientific presentation about clinical care for rheumatoid arthritis, i would do the facepalm headsmack, if my shoulder would let me. This was a crosssectional analytical study in which 5 patients with ra were clinically evaluated during two different sessions of. Patientreported outcomes pros aid in rheumatoid arthritis ra management, but it is not well understood which measures would be most relevant to the rheumatologists. Secular changes in the progression of clinical markers and. Sleep disturbances in patients with rheumatoid arthritis are related to fatigue, disease activity and other patient reported outcomes. This tool will be used by clinicians to improve process of care and outcomes in the management of ra. Patient reported outcomes from a phase 3 study of baricitinib versus placebo or adalimumab in patients with active rheumatoid arthritis and an inadequate response to background methotrexate. Introduction there is a worldwide interest about the evaluation of rheumatoid arthritis ra from the perspective of the patient, using patient reported outcomes pros, in order to assess disease. A reappraisal of haq disability in rheumatoid arthritis. Together, they provide comprehensive measurement of the disease. Relationship of patient reported outcomes with magnetic resonance imaging measures in rheumatoid arthritis joshua f. Health information technology has enabled efficient measurement of patient. The objective of this study was to identify and delineate relevant patient outcomes measured in studies that reported nursing interventions in patients with rheumatoid arthritis. Reported outcomes measurement information system promis was developed to improve measurement of patient.
Patients with ra were recruited to participate in focus groups from december 2014 to april 2015. Quantifiable measures of patients symptoms such as patient reported outcomes pros provides the physician with quantifiable information of. A prospective pilot study to evaluate an animated home. Patients with ra were recruited to participate in focus groups from december 2014 to april. Nov 12, 2019 stainesuponthames, united kingdom, nov. Patient reported outcomes in rheumatoid arthritis clinical trials. Assessing rheumatoid arthritis disease activity with.
Apr 18, 2018 to identify the perspectives of patients with rheumatoid arthritis ra on electronic recording of between. Outcome measures for use with patients with rheumatoid arthritis. Results of clinical and patientreported outcomes data for. Extended report relationship of patientreported outcomes. Relationship of patientreported outcomes with mri measures. Patientreported outcomes from a phase 3 study of baricitinib versus placebo or adalimumab in patients with active rheumatoid arthritis and an inadequate response to background.
Examining patientreported outcomes in rheumatoid arthritis. To determine whether patientreported outcomes may differentiate treatment response better than physicianreported outcomes for rheumatoid arthritis ra patients being. Relationship of patientreported outcomes with mri measures in rheumatoid arthritis joshua f baker,1,2,3 philip g conaghan,4 paul emery,4 daniel g baker,5 mikkel ostergaard6,7. Patient reported outcome measure rheumatoid arthritis warrior.
To determine if electronic versions of questionnaires assessing severity and impact of rheumatoid arthritis ra are equivalent to the original paper versions. Design a systematic search was conducted from 1990 to 2016. Rheumatoid arthritis ra is a systemic, inflammatory condition with shortterm and with longterm consequences for patients. Patient reported outcomes pros are outcomes assessed directly from the patient, without interpretation from the physician. We aimed to evaluate the agreement and correlation between pros and the physicians measurements. This was a crosssectional analytical study in which 5 patients with ra were clinically evaluated during two. Pain is one of the most pressing problems for rheumatoid arthritis ra patients and contributes substantially towards fatigue and disability. Philadelphia veterans affairs medical center, philadelphia, pa, usa 2. While some patients may experience chronic active states of disease while others may have long periods of remission in which symptoms are not active. Patient reported outcomes in a trial of combination therapy with etanercept and methotrexate for rheumatoid arthritis. Purpose we assessed whether mri measures of synovitis, osteitis and bone erosion were associated with patient reported outcomes pros in a longitudinal clinical trial setting among patients with rheumatoid arthritis ra. Digital tracking of rheumatoid arthritis longitudinally. In the past, most of the main information used when diagnosing and monitoring patients and assessing response to treatments came from the doctors evaluation along with the results of blood tests and imaging xray. Gomes, c codreanu, r pedersen, b freundlich, and s fatenejad.
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